Salem's Not-for-Profit Management Program began in 2006 and is the first undergraduate major in the field in the state of North Carolina. Students majoring in not-for-profit management at Salem will be prepared to manage organizations in the fields of advocacy, health care, philanthropy, private education, and religious and social service organizations.

This interdisciplinary program introduces students to “Third Sector” corporations and begins to prepare them to assume leadership roles in those organizations. Courses in not-for-profit management can be an excellent complement to many other majors, including American studies and history (for museum work); biology or chemistry (for work with environmental advocacy groups); or sociology (for work with social service agencies).